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nanoXIM HAp powders are micrometric aggregates of hydroxyapatite nanoparticles.

These products are used in the manufacturing of bone graft substitutes, such as porous granules and blocks scaffolds for bone regeneration.

Due to the similarity between nano-hydroxyapatite and mineralized bone, nanoXIM HAp powders have a high affinity to hard tissues as they form chemical bonds with the host tissue resulting in an improved biological performance.

 

 

   Benefits

 

Promotes fast bone regeneration and an early vascularization due to their osteoconductive and osteostimulative properties
Encourages protein adsorption and osteoblast adhesion
Enhances osteoblast functions
Biocompatible material
Resorbable material replaced by new bone during the healing process

 

   Features

 

Pure hydroxyapatite
Narrow particle size distribution
Nanostructured micron sized powder
High surface area (≥100 m2/g)
High porosity
Synthetic material

 

 

 

 

   Technical Data Sheet

 

nanoXIM•HAp200 is a series of nanostructured synthetic hydroxyapatite powders, manufactured and supplied in two different particle sizes, 5 and 10 μm.

This feature is achieved in the drying process by spray dryer technique where the nanoparticles in liquid phase are dried as spherical aggregates with a high surface area.

 

Reference  Particle size, d50 (μm) Specific surface area,
BET (m2/g)
Heavy metals,
as Pb (ppm)
nanoXIM•HAp202 5.0±1.0 ≥ 100 ≤ 20
nanoXIM•HAp203 10.0±2.0 ≥ 100 ≤ 20
Disclaimer: nanoXIM products are supplied in bulk and in non-sterile form.
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nanoXIM.HAp Powders

High Resolution SEM of
nanoXIM.HAp Powder

Electron crystallography image
of nanoXIM.HAp Powder

 

 

   Information Request


 

 

 

 

 

Applications of Nanostructured HAp for Osteogenesis and Angiogenesis

 

The formation of a stable microvasculature is an essential process to ensure a successful regeneration of bone tissue.

In this research, it was investigated the capacity of a 3D granules produced with nanoXIM•HAp202 to support both angiogenesis and osteogenesis.

For that purpose, a co-culture of human dermal microvascular endothelial cells (HDMECs) and human mesenchymal stem cells (HMSCs) was performed on nanoXIM•HAp202 granules.

 

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Substrates produced with nanoXIM HAp Powders provided an
adequate environment for the formation of mineralized tissue.

 

Improving Bone Regeneration Using HAp

 

The viability and proliferation of bone cells are essential during bone regeneration. In this study, it was evaluated the viability and proliferation of MG63 cells (osteoblast-like cells) cultured on substrates produced with nanoXIM•HAp202, in comparison with the ones produced with micro HAp.

The same features were also evaluated in collagen scaffolds and composite scaffold of collagen/nanoHAp.

In both cases the cell viability and proliferation was higher for the biomaterials containing nanoXIM•HAp202. Therefore, nanoXIM•HAp202 is a promising material to be used in bone regeneration applications.

 

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Osteoblast-like cells cultured on nanoXIM HAp granules showed an
increased cell adhesion and proliferation compared with micro HAp.
 

 

 

 

 

Ti6Al4V laser surface preparation and functionalization using hydroxyapatite for biomedical applications

D. Faria, C.S. Abreu, M. Buciumeanu, N. Dourado, O. Carvalho, F.S. Silva, G. Miranda, “Ti6Al4V laser surface preparation and functionalization using hydroxyapatite for biomedical applications”, J Biomed Mater Res Part B; DOI: 10.1002/jbm.b.33964 (2017).

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Effect of HAp and b-TCP incorporation on the tribological response of Ti6Al4V biocomposites for implant parts

T.A. Dantas, M.M. Costa, G. Miranda, F.S. Silva, C.S. Abreu, J.R. Gomes, “Effect of HAp and b-TCP incorporation on the tribological response of Ti6Al4V biocomposites for implant parts.” J Biomed Mater Res Part B; DOI: 10.1002/jbm.b.33908 (2017).

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Behavior of prostate cancer cells in a nanohydroxyapatite/collagen bone scaffold

S. Cruz-Neves, N. Ribeiro, I. Graça, C. Jerónimo, S. R. Sousa, F. J. Monteiro, "Behavior of prostate cancer cells in a nanohydroxyapatite/collagen bone scaffold”, Journal of Biomedical Materials Research Part A, DOI: 10.1002/jbm.a.36070, (2017).

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Electrochemical corrosion and bioactivity of Ti-NbSn-hydroxyapatite composites fabricated by pulse current activated sintering

W. Xiaopeng, K. Fantao, H. Biqing, C. Yuyong, “Electrochemical corrosion and bioactivity of Ti-NbSn-hydroxyapatite composites fabricated by pulse current activated sintering”, Journal of the Mechanical Behavior of Biomedical Materials (2017).

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Bioactive materials driven primary stability on titanium biocomposites

T.A. Dantas, C.S. Abreu, M.M. Costa, G. Miranda, F.S. Silva, N. Dourado, J.R. Gomes, “Bioactive materials driven primary stability on titanium biocomposites.” Materials Science and Engineering: C, 77(1), p. 1104 (2017).

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Antibacterial silk fibroin/nanohydroxyapatite hydrogels with silver and gold nanoparticles for bone regeneration

M. Ribeiro, M. P. Ferraz, F. J. Monteiro, M. H. Fernandes, M. M. Beppu, D. Mantione, H. Sardon, “Antibacterial silk fibroin/nanohydroxyapatite hydrogels with silver and gold nanoparticles for bone regeneration”, Nanotechnology, Biology and Medicine, 13, p. 231 (2017).

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Antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver, titanium dioxide and hydroxyapatite nanocoatings

A. Besinis, S. D. Hadi, H. R. Le, C. Tredwin, R. D. Handy, “Antibacterial activity and biofilm inhibition by surface modified titanium alloy medical implants following application of silver, titanium dioxide and hydroxyapatite nanocoatings”, Nanotoxicology, DOI: 10.1080/17435390.2017.1299890 (2017).

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Study of the tribocorrosion behaviour of Ti6Al4V – HA biocomposites

M. Buciumeanu, A. Araujo, O. Carvalho, G. Miranda, J.C.M. Souza, F.S. Silva, B. Henriques, “Study of the tribocorrosion behaviour of Ti6Al4V – HA biocomposites” Tribology International, 107, p. 77 (2016).

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Polysaccharide-coated liposomal formulations for dental targeting

S. Pistone, M. Rykke, G. Smistad, M. Hiorth, “Polysaccharide-coated liposomal formulations for dental targeting” International Journal of Pharmaceutics, 516, p. 106 (2016).

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S. aureus and E. coli dual-species biofilms on nanohydroxyapatite loaded with CHX or ZnO nanoparticles

J. Barros, L. Grenho, S. Fontenente, C.M. Manuel, O.C. Nunes, L.F. Melo, F.J. Monteiro and M.P. Ferraz, “S. aureus and E. coli dual-species biofilms on nanohydroxyapatite loaded with CHX or ZnO nanoparticles”, Journal of Biomedical Materials Research, Part A, 105A, p. 491 (2016).

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Novel bioceramic-reinforced hydrogel for alveolar bone regeneration

G. Iviglia, C. Cassinelli, E. Torre, F. Baino, M. Morra, C. Vitale-Brovarone, “Novel bioceramic-reinforced hydrogel for alveolar bone regeneration” Acta Biomaterialia 44, p. 97 (2016).

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Comprehensive Analysis of Secreted Protein, Acidic and Rich in Cysteine in Prostate Carcinogenesis: Development of a 3D Nanostructured Bone-Like Model

N. Ribeiro, P. Costa-Pinheiro, R. Henrique, M. Gomez-Lazaro, M.P. Pereira, A.A.P. Mansur, H.S. Mansur, C. Jerónimo, S.R. Sousa, F.J. Monteiro, “Comprehensive Analysis of Secreted Protein, Acidic and Rich in Cysteine in Prostate Carcinogenesis: Development of a 3D Nanostructured Bone-Like Model” Journal of Biomedical Nanotechnology, 12(8), p. 1667 (2016)

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Design of Ti6Al4V-HA composites produced by hot pressing for biomedical applications

G. Miranda, A. Araújo, F. Bartolomeu, M. Buciumeanu, O. Carvalho, J.C.M. Souza, F.S. Silva, B. Henriques, “Design of Ti6Al4V-HA composites produced by hot pressing for biomedical applications” Materials and Design 108, p. 488 (2016).

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Characteristics and in vitro response of thin hydroxyapatite–titania films produced by plasma electrolytic oxidation of Ti alloys in electrolytes with particle additions

W. K. Yeung, I. V. Sukhorukova, D. V. Shtansky, E. A. Levashov, I. Y. Zhitnyak, N. A. Gloushankova, P. V. Kiryukhantsev-Korneev, M. I. Petrzhik, A. Matthews, A. Yerokhin, “Characteristics and in vitro response of thin hydroxyapatite–titania films produced by plasma electrolytic oxidation of Ti alloys in electrolytes with particle additions”, The Royal Society of Chemistry Advances, 6, p. 12688 (2016).

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Biodegradation, biocompatibility, and osteoconduction evaluation of collagen-nanohydroxyapatite cryogels for bone tissue regeneration

C. L. Salgado, L. Grenho, M. H. Fernandes, B. J. Colaço, F.J. Monteiro, “Biodegradation, biocompatibility, and osteoconduction evaluation of collagen-nanohydroxyapatite cryogels for bone tissue regeneration”, Journal of Biomedical Materials Research A, 104(1), p. 57 (2016).

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In Vitro Cytokine Expression and In Vivo Healing and Inflammatory Response to a Collagen-Coated Synthetic Bone Filler

D. Bollati, M. Morra, C. Cassinelli, S.M. Lupi, R.R. Baena, “In Vitro Cytokine Expression and In Vivo Healing and Inflammatory Response to a Collagen-Coated Synthetic Bone Filler”, BioMed Research International, http://dx.doi.org/10.1155/2016/6427681 (2016).

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Composition for local and controlled release of drugs and methods thereof

F.J. Monteiro, S.R. Sousa, C.C. Coelho, N. Alegrete, “Composition for local and controlled release of drugs and methods thereof”, WO 2015162561A1.

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Antibacterial activity and biocompatibility of three-dimensional nanostructured porous granules of hydroxyapatite and zinc oxide nanoparticles—an in vitro and in vivo study

L. Grenho, C. L. Salgado, M. H. Fernandes, F.J. Monteiro, M.P. Ferraz, “Antibacterial activity and biocompatibility of three-dimensional nanostructured porous granules of hydroxyapatite and zinc oxide nanoparticles—an in vitro and in vivo study”, Nanotechnology, 26(31), p. XXX (2015)

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Anti-sessile bacterial and cytocompatibility properties of CHX-loaded nanohydroxyapatite

J. Barros, L. Grenho, M. H. Fernandes, C. M. Manuel, L.F. Melo, O.C. Nunes, F.J. Monteiro, M.P. Ferraz, “Anti-sessile bacterial and cytocompatibility properties of CHX-loaded nanohydroxyapatite”, Colloids and Surfaces B: Biointerfaces, 130, p. 305-314 (2015).

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Heparinized nanohydroxyapatite/collagen granules for controlled release of vancomycin

C.C. Coelho, S.R. Sousa, F.J. Monteiro, “Heparinized nanohydroxyapatite/collagen granules for controlled release of vancomycin”, Journal of Biomedical Materials Research Part A, 103(10), p. 3128 (2015).

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Transparent Hydroxyapatite Obtained through Spark Plasma Sintering: Optical and Mechanical Properties

Z. Li, K.A. Khor, “Transparent Hydroxyapatite Obtained through Spark Plasma Sintering: Optical and Mechanical Properties” Key Engineering Materials, 631 , p. 51 (2015).

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Nanohydroxyapatite based antibacterial surfaces to prevent biofilm associated biomaterials bone infection

L. Grenho, “Nanohydroxyapatite based antibacterial surfaces to prevent biofilm associated biomaterials bone infection”, PhD Thesis in Biomedical Engineering, Faculdade de Engenharia, Universidade do Porto (2015).

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Development of silk fibroin/nanohydroxyapatite composite hydrogels for bone tissue engineering

M. Ribeiro, M.A. de Moraes, M.M. Beppu, M.P. Garcia, M.H. Fernandes, F.J. Monteiro, M.P. Ferraz, “Development of silk fibroin/nanohydroxyapatite composite hydrogels for bone tissue engineering” European Polymer Journal, 67, p. 66 (2015).

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Tribocorrosion behaviour of hot pressed CoCrMo-HAP biocomposites

Z. Doni, A.C. Alves, F. Toptan, L.A. Rocha, M. Buciumeanu, L. Palaghian, F.S. Silva, “Tribocorrosion behaviour of hot pressed CoCrMo-HAP biocomposites” Tribology International, 91, p. 221 (2015). 

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Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler

M. Morra, G. Giavaresi, M. Sartori. A. Ferrari, A. Parrilli, D. Bollati, R.R. Baena, C. Cassinelli, M. Fini, , “Surface chemistry and effects on bone regeneration of a novel biomimetic synthetic bone filler” J Mater Sci: Mater Med 26(4), p. 159 (2015).

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Micro- and nano-hydroxyapatite as active reinforcement for soft biocomposites

F. Munarin, P. Petrini, R. Gentilini, R.S. Pillai, S. Dirè, M.C. Tanzi, V.M. Sglavo,“Micro- and nano-hydroxyapatite as active reinforcement for soft biocomposites”, International Journal of Biological Macromolecules, 72, p. 199 (2015).

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In vitro antimicrobial activity and biocompatibility of propolis containing nanohydroxyapatite

L. Grenho, J. Barros, C. Ferreira, V.R. Santos, F.J. Monteiro, M.P. Ferraz, M.E. Cortes, “In vitro antimicrobial activity and biocompatibility of propolis containing nanohydroxyapatite”, Biomedical Materials, 10, p. XXX (2015).

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HA/TCP scaffolds obtained by sucrose crystal leaching method: Preliminary in vitro Evaluation

L.R. Rodrigues, M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, C.A.C. Zavaglia, “HA/TCP scaffolds obtained by sucrose crystal leaching method: Preliminary in vitro Evaluation”, Materials Research, 17(4), p. 811 (2014).

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Sintering of Ceramic Materials Under Electric Field

K. Naik, "Sintering of Ceramic Materials Under Electric Field", PhD Thesis in Materials Science Engineering, Department of Industrial Engineering, University of Trento (2014).

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Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy

M.R. Davarpanah, H.A. Khoshhosn, M. Harati, S.A. Nosrati, M. Zoghi, M. Mazidi, M.G. Maragheh, “Optimization of fundamental parameters in routine production of 90Y-hydroxyapatite for radiosynovectomy”, Journal of Radioanalytical and Nuclear Chemistry, 302(1), p. 69 (2014).

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Influence of nanohydroxyapatite surface properties on Staphylococcus epidermidis biofilm formation

J. Barros, L. Grenho, C.M. Manuel, C. Ferreira, L. F. Melo, O.C. Nunes, F.J. Monteiro, M.P. Ferraz, “Influence of nanohydroxyapatite surface properties on Staphylococcus epidermidis biofilm formation”, Journal of Biomaterials Applications, 28(9), p. 1325 (2014).

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Thermal, creep-recovery and viscoelastic behavior of high density polyethylene/hydroxyapatite nano particles for bone substitutes: effects of gamma radiation

O.Y. Alothman, H. Fouad, S. M. Al-Zahrani, A. Eshra, M. F. A. Rez, S. G. Ansari, “Thermal, creep-recovery and viscoelastic behavior of high density polyethylene/hydroxyapatite nano particles for bone substitutes: effects of gamma radiation”, BioMedical Engineering OnLine, 13(1) p. 125 (2014).

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In vitro analysis of the antibacterial effect of nanohydroxyapatite–ZnO composites

L. Grenho, F.J. Monteiro, M.P. Ferraz, “In vitro analysis of the antibacterial effect of nanohydroxyapatite–ZnO composites”, Journal of Biomedical Materials Research Part A, 102(10), p. 3726 (2014).

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Influence of vancomycin controlled release from heparinized collagen/nanophased hydroxyapatite granules on osteoblast and osteoclast cells

K. Piedade, “Influence of vancomycin controlled release from heparinized collagen/nanophased hydroxyapatite granules on osteoblast and osteoclast cells”, Master Thesis in Pharmaceutical Biotechnology, Faculty of Pharmacy of Coimbra University, Portugal (2014).

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An experimental procedure for Reaction Injection Moulding – RIM – materials formulation design

M. V. Torres, “An experimental procedure for Reaction Injection Moulding – RIM – materials formulation design”, PhD Thesis in Chemical and Biological Engineering, Department of Chemical Engineering, University of Porto (2014).

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Response of Monocultured and Co-Cultured Human Microvascular Endothelial Cells and Mesenchymal Stem Cells to Macroporous Granules of Nanostructured-Hydroxyapatite Agglomerates

M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, “Response of Monocultured and Co-Cultured Human Microvascular Endothelial Cells and Mesenchymal Stem Cells to Macroporous Granules of Nanostructured-Hydroxyapatite Agglomerates”, Journal of Biomedical Nanotechnology, 9(9), p. 1594 (2013).

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A modular reactor to simulate biofilm development in orthopedic materials

J. Barros, L. Grenho, C.M. Manuel, C. Ferreira, L. F. Melo, O.C. Nunes , F.J. Monteiro, M.P. Ferraz, “A modular reactor to simulate biofilm development in orthopedic materials”, International Microbiology, 16(3), p. 191 (2013).

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Effect of gamma radiation and accelerated aging on the mechanical and thermal behavior of HDPE/HA nano-composites for bone tissue regeneration

O.Y. Alothman, F.N. Almajhdi H. Fouad, “Effect of gamma radiation and accelerated aging on the mechanical and thermal behavior of HDPE/HA nano-composites for bone tissue regeneration”, BioMedical Engineering OnLine, 12(95) (2013).

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Thermo-mechanical, Wear and Fracture Behavior of High-density Polyethylene/Hydroxyapatite Nano Composite for Biomedical Applications: Effect of Accelerated Ageing

H. Fouad, R. Elleithy, O.Y. Alothman, “Thermo-mechanical, Wear and Fracture Behavior of High-density Polyethylene/Hydroxyapatite Nano Composite for Biomedical Applications: Effect of Accelerated Ageing”, Journal of Materials Science & Technology, 29(6), p. 573 (2013).

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Preparation and characterization of collagen-nanohydroxyapatite biocomposite scaffolds by cryogelation method for bone tissue engineering applications

S.C. Rodrigues, C.L. Salgado, A. Sahu, M.P. Garcia, M.H. Fernandes, F.J. Monteiro.“Preparation and characterization of collagen-nanohydroxyapatite biocomposite scaffolds by cryogelation method for bone tissue engineering applications”, Journal of Biomedical Materials Research Part A., 101A(4), p. 1980 (2013).

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Microstructure and Biocompatibility of Ti-Nb-Si-HA Composites Fabricated by Rapid Sintering Using HEMM Powders

Woo, K.-D.; Kim, S.-H.; Kang, D.-S.; Kim, D.-G., “Microstructure and Biocompatibility of Ti-Nb-Si-HA Composites Fabricated by Rapid Sintering Using HEMM Powders”, Korean Journal of Materials Research 23(7) p. 353 (2013).

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Inducción de transparencia a cuerpos cerámicos de alto y bajo punto de fusión usando sinterizado convencional y por arco eléctrico SPS

H. G. Palacios, “Inducción de transparencia a cuerpos cerámicos de alto y bajo punto de fusión usando sinterizado convencional y por arco eléctrico SPS”, Master Thesis in Tecnología Avanzada, Centro de Investigación e Innovación Tecnológica, Instituto Politécnico Nacional, México (2013).

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Effects of Sn content on the microstructure, mechanical properties and biocompatibility of Ti–Nb–Sn/hydroxyapatite biocomposites synthesized by powder metallurgy

X. Wang, Y. Chen, L. Xu, Z. Liu, K.-D. Woo, “Effects of Sn content on the microstructure, mechanical properties and biocompatibility of Ti–Nb–Sn/hydroxyapatite biocomposites synthesized by powder metallurgy”, Materials & Design, 49 p. 511 (2013).

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Micropatterned silica thin films with nanohydroxyapatite micro-aggregates for guided tissue regeneration

A. Carvalho, A. Pelaez-Vargas, D. Gallego-Perez, L. Grenho, M.H. Fernandes, A.H. De Aza, M.P. Ferraz, D.J. Hansford, F.J. Monteiro, “Micropatterned silica thin films with nanohydroxyapatite micro-aggregates for guided tissue regeneration”, Dental Materials, 28(12), p. 1250 (2012)

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Synthesis and characterization of nanocrystalline hydroxyapatite gel and its application as scaffold aggregation

L.R. Rodrigues, M.A. Ávila, F.J. Monteiro, C. A. Zavaglia, “Synthesis and characterization of nanocrystalline hydroxyapatite gel and its application as scaffold aggregation”, Materials Research, 15(6) p. 974 (2012)

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Reciprocal interaction between human microvascular endothelial cells and mesenchymal stem cells on macroporous granules of nanostructured-hydroxyapatite agglomerates

M.S. Laranjeira, “Reciprocal interaction between human microvascular endothelial cells and mesenchymal stem cells on macroporous granules of nanostructured-hydroxyapatite agglomerates”, PhD Thesis in Biomedical Engineering, Faculdade de Engenharia, Universidade do Porto (2012).

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Staphylococcus aureus and Staphylococcus epidermidis adhesion to nanohydroxyapatite in the presence of model proteins

M. Ribeiro, F.J. Monteiro, M.P. Ferraz, “Staphylococcus aureus and Staphylococcus epidermidis adhesion to nanohydroxyapatite in the presence of model proteins”, Biomedical Materials, 7(4) (2012).

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Inclusão de células mesenquimais em scaffold de fosfato de cálcio para testes in vivo e in vitro

L.R. Rodrigues, A.B. Almeida, D.F. Feliciano, C.E. Raposo-Amaral, M.R. Passos-Bueno, B.V. Alamada, M.H. Fernandes, F.J. Monteiro, C. A. Zavaglia, “Inclusão de células mesenquimais em scaffold de fosfato de cálcio para testes in vivo e in vitro”, presented at the “7 Congresso Latino-Americano de Orgãos Artificiais e Biomateriais”, Natal, Brazil (2012).

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Synthesis and antibacterial activity of nanohydroxyapatite/ZnO nanoparticle composite

L. Grenho, F.J. Monteiro, M.P. Ferraz, “Synthesis and antibacterial activity of nanohydroxyapatite/ZnO nanoparticle composite”, European Cells and Materials, 23(S2), p. 17 (2012).

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Design of a modular reactor for biofilm formation studies in biomaterials

J. Barros, C.M. Manuel, L. Grenho, F.J. Monteiro, L. Melo, O.C. Nunes , M.P. Ferraz, “Design of a modular reactor for biofilm formation studies in biomaterials”, European Cells and Materials, 23(S2), p. 11 (2012).

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Influence of surface proteins on Staphylococcus epidermidis adhesion to nanohydroxyapatite as a substrate for bone regeneration

M. Ribeiro, F.J. Monteiro, M.P. Ferraz, “Influence of surface proteins on Staphylococcus epidermidis adhesion to nanohydroxyapatite as a substrate for bone regeneration”, European Cells and Materials, 23(S2), p. 25 (2012).

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Adhesion of Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa onto nanohydroxyapatite as a bone regeneration material

L. Grenho, C. Manso, F. J. Monteiro, M. P. Ferraz, “Adhesion of Staphylococcus aureus, Staphylococcus epidermidis and Pseudomonas aeruginosa onto nanohydroxyapatite as a bone regeneration material”, Journal of Biomedical Materials Research Part A., 100A(7), p. 1823 (2012).

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Preparation and in vitro biological studies of porous granules with nanostructured hydroxyapatite

M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, “Preparation and in vitro biological studies of porous granules with nanostructured hydroxyapatite”, Third I3S Scientific Retreat, Póvoa de Varzim, Portugal, p. 187 (2012).

Tribological behavior study on Ti–Nb–Sn/hydroxyapatite composites in simulated body fluid solution

C. Yuyong, W. Xiaopeng, X. Lijuan, L. Zhiguang, K. D. Woo, “Tribological behavior study on Ti–Nb–Sn/hydroxyapatite composites in simulated body fluid solution”, Journal of the Mechanical behaviour of Biomedical Materials 10, p. 97 (2012).

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Staphylococci adhesion on nanohydroxyapatite

L. Grenho, M.P. Ferraz, F.J. Monteiro, “Staphylococci adhesion on nanohydroxyapatite”, Bone, 48(S2), p. 240 (2011).

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Co-culture of human bone marrow stromal cells (HBMSC) and human dermal microvascular endothelial cells (HDMEC) on nano-hydroxyapatite (HA) surfaces

M.S. Laranjeira, F.J. Monteiro, M.H. Fernandes, “Co-culture of human bone marrow stromal cells (HBMSC) and human dermal microvascular endothelial cells (HDMEC) on nano-hydroxyapatite (HA) surfaces”, Histology and Histopathology, 26(S1) (2011).

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Preparation of collagen-hydroxyapatite biocomposite scaffolds by cryogelation method for tissue engineering applications

S.C. Rodrigues, A. Sahu, C.L. Salgado, F.J. Monteiro, “Preparation of collagen-hydroxyapatite biocomposite scaffolds by cryogelation method for tissue engineering applications”, Histology and Histopathology, 26(S1) (2011).

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Study of nanostructured hydroxyapatite based surfaces to prevent biofilm formation associated to implant infections

M. Ribeiro, “Study of nanostructured hydroxyapatite based surfaces to prevent biofilm formation associated to implant infections” MSc Thesis in Biomedical Engineering, Faculdade de Engenharia, Universidade do Porto (2011).

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Development of nanostructured and bioactive surfaces onto ceramic substrates

A. Carvalho, “Development of nanostructured and bioactive surfaces onto ceramic substrates”, MSc Thesis in Biomedical Engineering, Faculdade de Engenharia, Universidade do Porto (2011).

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Preparation and physicochemical/structural characterization of macroporous nanostructured-hydroxyapatite granules

M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, “Preparation and physicochemical/structural characterization of macroporous nanostructured-hydroxyapatite granules”, COLAOB Annals 2010, Rio Grande do Sul, Brasil.

Innovative macroporous granules of nanostructured hydroxyapatite agglomerates

M.S. Laranjeira, M.H. Fernandes, F.J. Monteiro, “Innovative macroporous granules of nanostructured hydroxyapatite agglomerates”, Journal of Biomedical Materials Research Part A, 95A(3), p. 891-900 (2010).

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Influence of crystallite size of nanophased hydroxyapatite on fibronectin and osteonectin adsorption and on MC3T3-E1 osteoblast adhesion

N. Ribeiro, S.R. Sousa, F.J. Monteiro, “Influence of crystallite size of nanophased hydroxyapatite on fibronectin and osteonectin adsorption and on MC3T3-E1 osteoblast adhesion”, Journal of Colloid and Interface Science , 351(2), p. 398-406 (2010).

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Synthesis and characterization of HAp nanorods from a cationic surfactant template method

J. M. Coelho, J. A. Moreira, A. Almeida, F. J. Monteiro, “Synthesis and characterization of HAp nanorods from a cationic surfactant template method”, J Mater Sci: Mater Med, 21(9), p. 2543-2549 (2010).

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Adhesion of different staphylococcus epidermidis strains to nano-hydroxyapatite

L. Grenho, M.P. Ferraz, F.J. Monteiro, “Adhesion of different staphylococcus epidermidis strains to nano-hydroxyapatite”, Poster presented at the “I3S Retreat”, Póvoa do Varzim, Portugal (2010).

Estudo da adesão bacteriana a biomateriais nanofásicos

L. Grenho, “Estudo da adesão bacteriana a biomateriais nanofásicos” MSc Thesis, Universidade Fernando Pessoa (2010).

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Human Fibronectin Adsorption onto Nanohydroxiapatite

N. Ribeiro, S. Sousa, F.J. Monteiro, “Human Fibronectin Adsorption onto Nanohydroxiapatite”, Poster presented at the “22nd European Conference of Biomaterials”, Lausanne, Switzerland (2009).